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EfficacyEfficacy DataTrial DesignClinical RemissionEndoscopic ImprovementBio/JAKi Subgroups DataIsolated ProctitisSafetyAdverse eventsCardiac and ocular adverse eventsGetting StartedResourcesEventsMaterialsVideos
Biologic/JAKi Subgroups Data

ELEVATE UC 52

ELEVATE UC 12

Tab Number 3

Tab Number 4

Tab Number 5

VELSIPITY efficacy in biologic/JAKi subgroups
Patients on VELSIPITY achieved clinical remission in both the biologic/JAKi-naive and biologic/JAKi-exposed subgroups in ELEVATE UC 521,2
Advanced therapies include S1P receptor modulators, biologics, and JAK inhibitors.3Clinical remission was defined as a stool frequency (SF) subscore of 0 (or of 1 with a ≥1-point decrease from baseline), a rectal bleeding (RB) subscore of 0, and an endoscopy score (ES) ≤1 (excluding friability).1Analysis of outcomes by prior treatment was not powered for statistical significance.3,4 Clinical remission was controlled for multiplicity via parallel gatekeeping procedures that preserved the type I error rate at 5%.3
VELSIPITY efficacy in biologic/JAKi subgroups
Patients on VELSIPITY achieved clinical remission in both the biologic/JAKi-naive and biologic/JAKi-exposed subgroups in ELEVATE UC 121,2
Advanced therapies include S1P receptor modulators, biologics, and JAK inhibitors.3Clinical remission was defined as a stool frequency (SF) subscore of 0 (or of 1 with a ≥1-point decrease from baseline), a rectal bleeding (RB) subscore of 0, and an endoscopy score (ES) ≤1 (excluding friability).1Analysis of outcomes by prior treatment was not powered for statistical significance.3,4
Clinical remission was controlled for multiplicity via parallel gatekeeping procedures that preserved the type I error rate at 5%.3
References:VELSIPITY (etrasimod) Summary of Product Characteristics. Brussels, Belgium: Pfizer Europe; February 2024.Sandborn WJ, Vermeire S, Peyrin-Biroulet L, et al. Etrasimod as induction and maintenance therapy for ulcerative colitis (ELEVATE): two randomised, double-blind, placebo-controlled, phase 3 studies [published correction appears in Lancet. 2023;401(10381):1000]. Lancet. 2023;401(10383):1159-1171. Supplementary appendix available at: https://www.thelancet.com/cms/10.1016/S0140-6736(23)00061-2/attachment/cdbbc759-490f-4b2a-a3a2-93bc9918b29f/mmc1.pdf. Accessed December 18, 2023.Sandborn WJ, Vermeire S, Peyrin-Biroulet L, et al. Etrasimod as induction and maintenance therapy for ulcerative colitis (ELEVATE): two randomised, double-blind, placebo-controlled, phase 3 studies [published correction appears in Lancet. 2023;401(10381):1000]. Lancet. 2023;401(10383):1159-1171.Data on file. Pfizer Inc.
Isolated Proctitis

See how VELSIPITY is effective in calming the chaos of isolated proctitis.

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